Menopause-related signs and symptoms such as weight gain, night sweats, hot flashes, and reduced sexual functioning all have passive effects on “life quality", and impacts daily activities such as leisure activities, work, and sleep. The Aims of the study were to determine the effect of lifestyle modification on promoting life quality and improving health promotion behaviors among postmenopausal women. The quasi-experimental study with “pre-posttest" design was utilized at primary and secondary schools in Menoufiya Governorate- Shebin Al-Kom- Arab Republic of Egypt. A total of 200 postmenopausal women between 45 to 60 years of teachers and employee were recruited in the study. Four tools were developed and used for data collection; 1) A structured Interviewing Questionnaire, 2) Menopause Rating Scale; 3)Utain Quality of Life Scale 4) Health Promoting Lifestyle Profile. Results showed thatthere were statistically significant differences between the control and intervention groups regarding promoting life quality and improving health promotion behaviors before and after the nursing intervention. The study concluded thatthe healthy lifestyle modifications improved scores of life quality among postmenopausal women in immediately and three months after the nursing intervention. Therefore these modifications can be used by all postmenopausal women to improve their health and fineness of life.