Professional ethics is an important aspect in health care system as professional ethics help in improving the quality of patient care and enhance job satisfaction among nurses and patients. The purpose of the study was to assess awareness and compliance about professional ethics as perceived by nursing personal and patients. A descriptive design was utilized to meet the purpose of this study. Setting the study conducted at Medical and Surgical departments at Benha University Hospital. The sample of this study included 240 staff nurse, 60 head nurses and 80 patients. It was conducted at Benha University Hospital. Instruments: Two Instruments were used for data collection of this study namely (Nursing Professional Ethics Questionnaire and Professional Ethics Compliance Questionnaire). The results showed that nursing personnel had a moderate awareness level in relation to professional ethics; there was a statistical significant relation among nursing personnel awareness and their compliance regarding professional ethics.  Patients had moderate awareness regarding nurse's compliance about professional ethics. This study concluded that head nurses total awareness and compliance was higher than staff nurses in relation to professional ethics. This study recommended that: In-service training and educational opportunities about professional nursing ethics should be provided for nurses.