Many patients on regular hemodialysis have sleep disorders, which not only affect their quality of life but also their immune function. Relaxation techniques are simply designed to teach the patients to relax, and thus improve their ability to sleep. The purpose of the study was to evaluate the effect of relaxation techniques on the quality of sleep of patients with end stage renal failure undergoing hemodialysis.  The study was carried out in hemodialysis unit at Mobark Hospital, Tanta University Hospital. A convenient sample of 20 adult patients undergoing hemodialysis was selected, with one group, before and after intervention. Two instruments were used for data collection. Instrument one includes Scio demographic data assessment. Instrument two includes Pittsburgh Sleep Quality Index Scale that measures the sleep quality. The main result showed that relaxation technique improved the total score of sleep quality and its dimensions in hemodialysis patients. It is recommended that Periodic clinical assessment of sleep complaints should become routine for dialysis patients. Also, no pharmacological methods such as relaxation techniques should be used for the treatment of sleep problems in hemodialysis patients.