Nursing productivity refers to effectiveness of nursing care which relates to this quality and appropriateness and efficiency of care. The purpose of this study was to investigate work design and its relation to productivity among staff nurses. . Design; a descriptive co-relational research design. A convenient sample of 400 staff nurses was selected to carry out this study. Setting; this study was conducted at Menoufia University Hospital at Shebin El-Kom , Menoufia Governorate, Egypt. Two instruments were used to conduct the study for work design questionnaire and productivity questionnaire. Results: there was a positive statistically significant correlation between studied staff nurses' work design and productivity. The majority of studied staff nurses had moderate levels of work design characters; the first ranking with the highest mean score was social characteristics while the last ranking was task character. Moreover, more than two third of studied staff nurses had low levels of productivity, nearly one fifth of them had moderate level of productivity. Otherwise, the minority of them had high levels productivity.  Additionally, the first ranking of productivity was work organization and the last ranking with the lowest mean score of productivity was working conditions. Conclusion: there was positive highly statistically significant correlation between work design and staff nurses' productivity. Recommendation; continuing education programs and training courses for nurse manager and their staff about  work design character and productivity.