Nurses should work at safe environment to maintain high work life quality and good patient care delivery. The purpose of the study: Is to determine the relationship between work hazards and quality of nurses' work life.  Methods:  A descriptive correlational design was used; the study was conducted in operating rooms at Menoufia university hospitals. A convenient sample of 92 nurses were recruited from operating nurses. Data was collected using three Instruments (two structured questionnaires and one observation checklist) adapted by the investigator. The first structured questionnaire was work hazards questionnaire. The second structured questionnaire was quality of work life questionnaire. The third Instrument was observation checklist to assess OR environment safety and nurses' compliance to safety measures. Results: Majority of the studied subjects exposed to high work hazards and low work life quality. Conclusion: There is a very highly statistically significant negative correlation between work hazards and quality of work life. Recommendations: Maintain safe work environment at operation rooms to increase quality of nurses' work life.