Background: The setting a rounding ICU staff nurses has been showed like a rapid changed and unexpected and staff
nurses' perceptive burden as predictable weighty. Research of interruption and multitasking in health care setting are
restricted and mainly concentrate on practitioner. Aim of study: The aim of study is to determine relationship between
workflow interruptions and nursing error among staff nurse in ICU. Methods: A descriptive correlational study design
was conducted with a convenient sample of (65) staff nurses worked in adult medical, surgical, and child intensive care
units at Oncology Center of Mansoura University. Data was collected using two tools. The first tool was an
Interruption observation sheet, and second tool was Nursing errors categories questionnaire sheet. Results: Regarding to
source of interruption, the highest source is internal interruption, while the lowest source is patient related interruption.
Regarding to types of nursing errors, main errors category of staff nurses was related to documentation errors followed
by medication errors. There were statistically significant positive correlations between overall workflow interruption
and overall nursing errors. Conclusion: It was concluded that increase rate of interruption occurrence causing increase
incidence of errors. Recommendations: The study recommended that design a training schedule for staff nurses to
modernize their information and expertise so as to improve patient's outcome for evading error occurrence related to
interruption, and align staff nurses behavior, rights, duties, and values with the health care system policies, goals, and
objectives in order to reduce effect of internal interruption.