Background: Ulcerative colitis is the most common type of inflammatory bowel disease affecting a person's social and
psychological wellbeing, quality of life and educational performance. Aim of the study: Evaluate the effect of
educational instructions on knowledge of patients with ulcerative colitis. Methodology: Quasi–experimental design was
conducted at inpatient and outpatient clinic in Specialized Medical Hospital at Mansoura University. Purposive sample
of 50 patients who were willing to participate in the study according to inclusion and exclusion criteria. Tool: One tool
structured questionnaire sheet was used in this study. Results: The present study showed statistically significant
improvement in patient's knowledge level noticed in posttest and follow up after implementation of educational
instructions. Conclusion: The study concluded that there was a positive effect of educational instructions on improving
knowledge level among ulcerative colitis patients. Recommendation: It was recommended that all ulcerative colitis
patients have access to a basic-colored educational leaflet published in simple Arabic language