Background: Safe patient handling and movement is very important part of the organizational culture. It is basic
element and guide to improve nurse knowledge. Aim of the study: Evaluate the effect of nursing guidelines on
orthopedic nurses' knowledge regarding safe patient handling and movement. Design: Quasi-experimental research
design was utilized in this study. Setting: This study was conducted in orthopedic departments at Mansoura University
Hospital. Subject: All available number of nurses (50) working in orthopedic department. Tools: One tool structure
questionnaire sheet was used in this study. Results: The present study revealed that more than half of studied nurses' had
fair knowledge pre intervention compared to above two third had good knowledge post intervention. Conclusion: It can
be concluded that there was a positive effect of nursing guidelines on improving nurses' knowledge regarding safe
patient handling and movement. Recommendations: This study recommended the availability of written guidelines
regarding safe patient handling and movement in orthopedic department.