Background: Stomatitis is probably the most prevalent, debilitating complication of
cancer treatments particularly chemotherapy. Aim: This study aimed to examine
effectiveness of flavored oral cryotherapy on the prevention and management of stomatitis
induced by chemotherapy. Method :A quasi experimental design was conducted on a
purposive sample of 46 children from both gender with cancer and undergoing
chemotherapy who attended the pediatric outpatient clinics and in-patient pediatric
oncology department in Oncology Center at Mansoura University and their age from 6-18
years, newly diagnosed with cancer and in induction stage of chemotherautic protocol, had
a healthy oral mucosa and treated with methotrexate, Adriamycin or 5-Fluorouracil.
Tools: A structural interview questionnaire sheet about characteristics, clinical data and
oral health status of children and oral assessment guide tool (OAG). Result: More than
half of children in flavored cryotherapy had healthy oral cavity while nearly two third of
them had sever stomatitis at 14th day. Conclusion: Using flavored oral cryotherapy lead to
healthier oral mucosa and lower stomatitis score compared to using only mouthwash
(chlorhexidine). Recommendations: Provide in-services, up to date, regular training
programs to improve nurses' knowledge and practices regarding the use of flavored
cryotherapy and mouthwashes as routine care for children treated with chemotherapy