Hemodialysis (HD) is one of the most important and effective treatment modalities that can help to sustain life of end stage renal disease patient. A large number of HD patients suffer from uremic pruritus(UP). Patient education is an important aspect of clinical management that encourages a continuous and interactive process that looks to improve the patient's lifestyle and thereby prevent or decrease the UP related complications.Aim of this study:Evaluate effect of uremic pruritus educational interventions on knowledge level for hemodialysis patients.Method: Quasi experimentalresearcherdesign was used in this study. Setting:The current study was conducted in hemodialysis unit at General Kafr Elsheikh governorate hospital.Sample:A purposive sample of (80) HD patients with uremic pruritus was randomly divided into two groups with equal size.Tools: Interview questionnaire sheet consisted of three parts such as demographic data, medical data, and assessment of patient knowledge.Results: The current study showed that the average knowledge scores are nearly the same in both study and control groups at pretest, while at posttest there was a statistical significant difference between study and control groups as the average knowledge scores are significantly higher in study group compared to control group. Conclusion: Hypothesis of the current study was accepted as patients who receive the uremic pruritus educational interventions have an increased level of knowledge.