Background: About 200 to 800 million people in the world have some form of thyroid disease (Vanderpump, 2011). Aim: The current study aimed to examine the effects of health teaching handouts on patients' outcome who undergoing thyroidectomy in General Surgical Departments at Mansoura University Hospitals. Design: A quasi experimental research design was used. Setting: This study was conducted at the General Surgical Departments at Mansoura University. Subjects: Purposive sample was used and consist of forty-two patients. Tools: Assessment Questionnaire Sheet. It was consisted of three parts to measure the following; general characteristics, the past and present history, and patient knowledge about discharge care. Findings: The majority of the studied patients have poor knowledge about thyroidectomy care pre using of the health teaching handouts, whereas, more than half of the studied patients have fair knowledge about thyroidectomy care post using of the health teaching handouts. There is a highly significant relation between patient's knowledge post using health teaching handouts on thyroidectomy care. Recommendations: Simple handouts as booklets and brochures about thyroidectomy care should be developed and distributed at the surgical units. Evidence-based thyroidectomy care guidelines should be integrated in medical surgical courses curriculum for nursing students.