Background: Sexual health is a basic human right and a fundamental part  of  a  full healthy life. Patients with Chronic kidney disease (CKD) world-wide  suffer  many  physical  dysfunctions  including  sexual  activity.  Therefore,  this   study   aims   to   assess  the  psychosexual  dysfunctions  experienced  by   hemodialysis   male   patients  and their coping strategies. Methods: A descriptive research design is conducted in the hemodialysis  units  at  Urology and Nephrology  Center  at  Mansoura  University.  The  data  were  collected from  100  hemodialysis  male  patients.  The  study   Tools   included   the   Arizona Sexual   Experience   Scale   (ASEX),   the   Psychosexual   Dysfunction   Questionnaire and the Brief Cope Scale (BCS). Results: Obtained results  revealed  that  most  of  the  study  of  sample  (94%)  complained of many psychosexual  dysfunctions  while  only  6%  expressed  no  significant psychosexual dysfunctions. The  studied  patients  used  problem  focused coping by 76% with total mean of (18.36)  out  of  a  possible  score  of  (24).  On  the  other hand, the studied patients  used  emotional  focused  coping  by  57%  with  total mean of (50.24) out of a possible score of (88). Conclusion:  The  vast  majority  of  the  study  sample  does  suffer  multiple  psychosexual  dysfunctions.   Both   physical   and   psychological   distress   increase  CKD male patients' psychosexual  dysfunctions  and  indicate  the  necessity  of  introducing  psychiatric  liaison  nursing  programs  to  enhance   their   coping   strategies in the hemodialysis care units.