Aim of this study was to compare the effect of maternal semi sitting versus lithotomy position during second stage of labor on maternal outcomes. Subjects and method: A quasi-experimental study was conducted at the Labor and Delivery Room of Mansoura University Hospital, on a purposive sample of 96 parturient women in active labor; 48 assigned to study group by assuming the semi sitting position during second stage of labor, while the control group (n=48) adopted the conventional lithotomy position. Data were collected using three tools; a structured interview questionnaire, Visual Analogue Scale for pain and satisfaction with the assumed position scale. Results: The intervention group had more efficient contractions, shorter 2^nd stage duration, less perineal lacerations, lower labor pain scores and higher satisfaction scores compared to those of the control group. Conclusion and recommendations: Positioning of parturient women in semi sitting position had a positive impact on maternal outcomes and woman's satisfaction with the care provided. Accordingly, semi sitting position would be an integral part of the nursing care during second stage of labor.