Background: Nurse–physician relationship is particularly important, given the interdependence of the two professions and the primary role they play in safe, quality patient care. The well-entrenched hierarchical authority structure and sexism complicate nurse–physician relationship . Unfortunately, disruptive communication occurs with alarming frequency in both nurses and physicians, and both sets of professionals agree that such ways of communicating decrease patient safety. Aim of the study: To evaluate nurse physician relationship and its impact on their perception of nurse`s role. Subjects and method: A descriptive design was used to carry out this study. The study was conducted at El-Mansoura Health Insurance hospital study subjects were included all 250nurses and all 100physicians. One tool was called nurse physician relationship and its impact on their perception of nurse role questionnaire sheet. Results and Conclusion: The finding of the present study indicated that physicians scored higher mean score related to nurse physician relationship than nurses. The level of nurse physician relationship from the majority of physicians and the nurses was moderate. Recommendation: improving collaborative relationship between nurses and physicians through Understand each other's roles.