Background: Human reproduction involves a man and a woman. Since men participate in sexual decisions and behavior associated with reproduction then reproductive health is a concern for all men of all ages. Therefore the earliest part of the life course adolescence and early adulthood is important because it is the most fascinating and complex transitions (physical, psychological and behavioral) in the life span. Promoting the sexual and reproductive health of young men is a keystone to enhance their health overall, to reduce some of the major health risks they face, and to establish habits that will protect them throughout their lives. Proper information about this subject can help them to handle these changes without any stress. For that the aim of this paper is to assess the application of health education package about sexual and reproductive health for University male students'. Method: A quasi-experimental (one group, pre post-test) research was used. The minimum sample size comprised 381 students. Proportion allocation technique was used to select the required students' number of first, second and third year at studied faculties. A total number of students sample was 386 students. Three tools were used for data collection: Structured self-administered questionnaire to assess male students' socio- demographic and economic characteristics, structured self-administered questionnaire to assess male students' knowledge and self-administered scale to assess male students' attitude. Results: There was highly statistical significant difference in knowledge level before and after application of educational package about sexual and reproductive health (t=151.995, P≤ 0.01). Concerning attitude of students toward sexual and reproductive health, there was significant differences before and after application of educational package (p < 0.001). Conclusion: The study concluded that almost all university male students had poor knowledge score level about sexual and reproductive health before application of education package and all of them had good knowledge score level after application Recommendations: Academic learning should be occupied with sexual and reproductive health. Provide proper information for adolescent boys about sexual and reproductive health and guidance about their sexual responsibilities and relationships. Develop global service education package about sexual and reproductive health for adolescent boys and men to support providers of this subject meet the specific and diverse needs of them. Conducting Public health campaigns about the impact of denial sexual and reproductive health on adolescents.