Background: Stress is one of the main factors affecting nurses 'personality profile with others psychiatric distress of depression and anxiety as well as neuroticism and emotional stability profile. Aim: This study aimed to examine the influence of personality traits on the development of depressive state and Anxiety distress among nurses. Subjects and Method: Descriptive correlational design was used: (102) nurses in El-Mahala General Hospital were choosing according to inclusion criteria. The instruments used for data collection were, socio-demographic data sheet, the Eysenck personality inventory test (EPI)-57 and Depression Anxiety Stress Scale DASS-21. Results: revealed that there was a statistical significant relation of personality profile and psychological distress. Conclusions: most common personality profile of the nurses was introversion neuroticism with positive correlation between anxiety, depression and stress disorders.