Background: Today, nursing staff's loyalty is one most difficult problems that troubles head nurses. Several ways are proposed to solve this problem, among which improving style of leadership as a key perspective, for that to, leadership style determines the relationship between head nurses and nursing staff . Aim: The study aimed to explore relationship between leadership styles and nursing staff loyalty at Mansoura Health Insurance Hospital. Methods: Descriptive Correlation design study was used and conducted on 300 of staff nurses working at Mansoura Health Insurance Hospital, using two tools: Multifactor Leadership Questionnaire (MLQ) and Loyalty to Head nurse Scale (LS). Results: revealed that there was statistically significant (P<0.05) correlation between leadership styles and loyalty. The findings of the study showed that nurses will be satisfied when head nurses using transformational leadership style followed by laissez-faire leadership style. Conclusion: the study concluded that there is statistical significant correlation between head nurses' leadership styles and nursing staff loyalty at Mansoura Health Insurance Hospital. Recommendation: The head nurse should know the necessary element for the nursing staff and the hospitals and stimulate the nursing staff to search the opportunities around them effectively. The hospital and head nurses should share the decisions and the leadership with the nursing staff. Beside, present the training and facilitation for the team. In addition, The practices and the polices should associated with the feedback system and the rewarding to satisfy the needs of the nursing staff for developing the loyalty for the nurses.