Background: Adolescence refers to a sensitive stage of life in which adolescents of both sexes experience various changes in their bodies . The present study aims to identify sexual knowledge versus attitudes of female adolescents towards sexually transmitted diseases . Descriptive comparative study was conducted on a sample of 154 students ( 77 nursing and 77 art ) at the faculty of nursing and faculty of arts at Zagazig University . Two tools were used , a structured interview questionnaire sheet and attitude scale . The results revealed that 85.2% of female nursing students, mothers who had finished their secondary education compared to 39.4% of art students, mothers had good sexual knowledge. Also, 50% of nursing students and 35.3% of art students who had high social class had positive sexual attitudes. There was a statistically significant difference between female adolescent, residence and their sexual knowledge for both nursing and art students. It can be concluded that more than two thirds of nursing students and less than one third of art students had good sexual knowledge. Concerning to overall attitude scale , there was a statistically significant difference between both nursing and art students groups . Therefore , the study recommended that Pediatric nurse , Psychiatric nurse , Community health nurse and School health nurse should offer sexual health teaching services for adolescents .