The presence of a permanent colostomy often leads to inevitable changes led to maladjustment and disordered bodily function. In addition to disruption of a number of aspects of the patients' private lives that will affect the patient's ability to perform self- care. Supportive nursing measures are essential to teach patients with colostomy how to integrate self- care into daily activities for enhancing self care abilities, improving outcomes and decrease unnecessary hospitalization that can have a positive effect on lifestyle modification and the quality of life. The aim: Determine the effect of supportive nursing measures on self- care practices among adult colostomy patients. Settings: The study was carried out in the in-patient at the general surgical wards and in surgical out patients' clinics at the Main Mansoura University Hospital using Quasi-experimental research design. Subjects: 60 adult colostomy patients with permanent colostomy were randomly divided into study and control groups (30 patients in each). The data was collected for duration of one year and six months. Tools: Four tools were used for data collection; Bio-socio-demographic data sheet; Ostomy patient's knowledge questionnaire; Universal Self- Care Activities Check Lis and Ostomy Self-care Practices Check List. Results: The study findings revealed high statistical significant differences in favor of the study group regarding ostomy knowledge, practices of ostomy self care in addition to social, psychological and sexual status. Conclusion: The study group who had taken supportive nursing measures sessions experienced high significant positive impacts on their ostomy knowledge, self-care practices, psychosocial and sexual status than control group. Recommendations: Establish in colorectal surgical unit Supportive nursing measures by qualified Enterstomal nurse with necessary comprehensive reference materials.