Background: Pressure ulcers are common health problems that represent a nursing and social burden. Mortality risk in a patient with pressure ulcer is 2 to 6 times greater than this in a patient with intact skin. The Aim of the study is to evaluate the effect of implementing nursing care guidelines for pressure ulcers prevention to orthopedic immobilized patients. Method: Quasi-experimental research design was used to conduct this study in orthopedic unit at Mansoura Emergency Hospital. The sample of this study was consisted of 74 patients, divided into study and control groups equally. Results and Conclusion: There was statistically significant difference between the study and control groups regarding post-implementation of pressure ulcer prevention guidelines. Recommendations: Nursing care guidelines for prevention of pressure ulcers should effectively be implemented for orthopedic immobilized patients who are assessed as being at pressure ulcers risk.