Background: Paracentesis is an essential life measure for ascites complications management. The aim: of this study was to apply nursing safety measure to prevent complication for liver cirrhotic patient undergoing paracentesis. Methodology: Quasi- experimental design was utilized. Study subjects: All available nurses were included (55) nurses. Two tools: Nursing interviewing questionnaire and observational checklist for nurse's practices for cirrhotic patients undergoing paracentesis. Results: The present study revealed that nurses had highly statistically significant improvement in total level of knowledge and practice post implementing nursing education. The study concluded: There was a statistically significant positive effect on nurses' knowledge and practice for patients undergoing paracentesis after education. The study recommended: Providing specific courses and periodical follow up for enhancing nurses' knowledge and practice.