Background;Asthma is a chronic inflammatory disorder of the airways Asthma has a genetic predisposition but it needs environment factors, it is one of themostcommom chronic diseases of the children.The aim of the study;was to assessthe nursing care provide for children suffering from bronchial asthma,developed implement and evaluate effect evidence -based guidelines for nurses caring for children suffering from bronchial asthma. Design; A quasi experimental design was used. Setting; this study conducted atat the Inpatient Pediatric Medical Unit, Emergency Unit and Out Patient Clinic atBenha University Hospital and Benha specialized children hospital. Sample; A purposive sample including 48 nurses hwo have working with children with asthma and their children were from both sexes ,their ages ranged from 3-6years.Tools; three tools were used for data collection(1): A structured interview questionnaire sheet which contain part one : the personal characteristics of nurses working with children with asthma,personal characteristics of children , medical history of children , part two: nurses'knowledge regarding to asthma asdefinition,causes, syptomes (mild,modrerd and sever)complication and medication (2): Observation checklist (3): Evidence based guidelines. Results;There is a highly statisticallysignificant positive relation between total knowledge score level and total practice score in pre and post evidence - based guidelines of asthma. Conclusion;The designed evidence - based guidelines lead to significant improvement of nurses' knowledge and practices after implementation of the evidence - based guidelines of asthma. Recommendations;Updated guidelines and continuous in-service educational programs for nurses' performance in caring of children with asthma