Aim of the study: Assess compliance of hemodialysis patient to the therapeutic regimen. Study design: A descriptive study was followed in this study. Study subjects: A sample composed of 120 adult hemodialysis patients and met inclusion criteria were included in this study. Settings: The study was done at hemodialysis units at Urology and Nephrology Center- Mansoura University. Tool of the study: two tools were used, interview questionnaire and Compliance scale. Results: The result revealed that (46.7%) of patients were in age group from 40 to < 50 years, (58.3.%) were males and (30.8%) were illiterate. Result also showed that (64.25%) were compliant while (35.8%) of them were non-compliant. Conclusions: present study illustrated that more than one third of hemodialysis patients didn't comply with therapeutic regimen. Hence, they also didn't follow the correct practice related to therapeutic regimen. Recommendations: Family counseling and social support network should be strengthen in health promotion programs to improve their quality of life.