Bronchial asthma (BA) is one of the most common chronic lung diseases, in both the developed and developing countries. There has been a sharp increase in the global prevalence, morbidity, mortality, and financial burden associated with asthma. Buteyko Breathing Technique (BBT) is the most effective a natural drug-free alternative therapy for asthma management. BBT showed a significant improvement in quality of life (QoL) and asthma control. This study aims to assess the effect of BBT on quality of life in patients with bronchial asthma. Subjects & Methods: Quasi-experimental design was conducted. A purposive sample of 90 asthmatic patients was included from out-patients of chest diseases department, Mansoura university Hospital over a period of 12 months. Data were collected using one tool "Patients' Interview Assessment Sheet" which include 2 parts 1) Socio demographic data, 2) Quality of Life Questionnaire (pre-test, and post-test). Results: revealed that, improvement of QoL total score 49.2 ± 8.4 to reach 60.4 ± 12.9 post implementing BBT compared to 51.5 ± 8.6 to reach 53.5 ± 9.1 of the control group after three months. Conclusion: The intervention group shows significant improvement of total quality of life scores Recommendations: further studies to investigate the impact of BBT on patients of bronchial asthma on long run studies.