Present study aims to assess the severity of autistic symptoms and adaptive behavior and the relationship between the two variables among Egyptian sample of children with Autism Spectrum disorder (ASD). A descriptive study was utilized with a sample of
(28) children diagnosed with ASD by a consultant psychiatrist at "Maharaty center" in "Alzhour Association for community development". It's a governmental association affiliated to the Ministry of Social Affairs. Data collected using three tools, one for assessing socioeconomic status scale for health research in Egypt, the second for assessing the severity of autistic symptoms using Gilliam Autism Rating Scale (GARS), and the third for assessing adaptive behavior using Vinland Adaptive Behavior Scale (VABS). Results reveals that the severity of autistic symptoms correlate significantly and negatively with communication, daily living skills and social behavior where no significant relation between severity of autistic symptoms and motor skills. In conclusion, there is a significant negative relationship between severity of autistic symptoms and adaptive behavior. Therefore, it is recommended for nurses to enhance adequate training about adaptive behavior for those children to minimize their dependence and disability.