Diabetes is a syndrome constituting a general public health problem and it's difficult for diabetic individual, their family to adhere to self-management and person with diabetes may face many barriers to perform optimal diabetes self-management. The aim of the study was to assess barriers to self-management among patients with type 2diabetes mellitus (T2DM). Materials and method: Descriptive research design was utilized to conduct this study. Sample: convenience sample of 100 adult patients from both sexes diagnosed with T2DM conducted in diabetic unit and clinic at specialized medical hospital in Mansoura University Hospital. Data were collecting using two tools; first tool was patient's health relevant information interview and second tool was patient's barriers to self-management. Result: There are many barriers affecting type 2 diabetic patients to participate in self- management and majority of the patients have insufficient or lack of adherence to self – managements and facing many barriers as educational, physical, psychosocial, financial and cultural barriers.