Background: Pre menstrual syndrome can affect adolescent girl health and have significant impact on adolescent girl's quality of life. Aim of the study was to assess the effect of pre menstrual syndrome on quality of life of adolescent girl. This aim was achieved through, assessing adolescent girl's health condition regarding pre menstrual symptoms and assessing the effect of pre menstrual syndrome on quality of life on adolescent girls. Descriptive design was used to achieve the aim of the study. Setting, the study was conducted at the secondary technical nursing school at Benha university hospital. Purposeful Sample included 200 nursing students, with pre menstrual syndrome, unmarried girl and free from any medical and obstetrics disorders that affect quality of life. Tools included structured interviewing questionnaire, pre menstrual self evaluation questionnaire, and the medical outcome study short form-36(SF-36) . Results:80%aged more than 16 years with the mean age is 17.61 ±1.13,64% menstruated at11-13 years with the mean age is 13.32 ±1.22, highly significant difference between the studied girls and pre menstrual syndrome physical and psychological symptoms P<0.001, Quality of life score indicated that there were decline in all dimensions of life quality as degree of pre menstrual syndrome worsen among adolescent girls. Conclusion: pre menstrual syndrome during adolescence affect adolescent girl's quality of life and well-being. Recommendation: establish educational program for adolescent girl regarding managing pre menstrual syndrome