Background: Cerebral palsy (CP) is a group of permanent and non-progressive disorder of movement and posture caused by a central nervous system lesion, damage or dysfunction originating early in life so, educating caregivers important to improve their practices and consequences children QOL. Aim of study: Evaluate the effect of an educational program on mothers' care for their children with cerebral palsy and its effect on their quality of life. Methods: A quasi-experimental design was used including 50 mothers having cerebral palsy children. The tools of data collection were mothers and child assessment sheet that constructed by the researcher and Cerebral palsy quality of life questionnaire. Results: The results showed significant improvement in mothers' knowledge and reported practice regarding care of their children with CP, and also showed slightly improvement in children's quality of life after program implementation. Conclusion: There was a positive effect of the educational program in improving mothers' knowledge & reported practice regarding CP and slightly improvement related to children's quality of life. Recommendation: Continuous educational programs should be provided for mothers of cerebral palsy children about care of their children in order to improve their quality of life. Nurses in the physiotherapy clinic, outpatient clinic, and pediatrics department should trained well and supplied with information and training CP program as they are the main source of the mothers' information during providing the child by needed care.