Acute bleeding from esophageal varices is often a dramatic event. Dependent on the amount of lost blood, patients might be hemodynamic instable and present in hemorrhagic shock. Thus, the management of patients with acute variceal bleeding includes not only treatment and control of active bleeding but also the prevention of rebleeding, infections and renal failure. The aim of this study was to assess the effect of discharge planning for patients with esophageal varices on compliance to therapeutic regimen. Subjects and Methods: A purposive sample of 100 esophageal varices patients in GIT endoscopy unit and internal medicine units at Benha University Hospital over a period of 12 months. Data were collected using I) Interview questionnaire sheet to assess patients' knowledge, which include two parts 1) Socio demographic characteristics related to patients and 2)Structured Knowledge Questionnaire, II) Compliance assessment sheet to assess compliance of patients with esophageal varices to therapeutic regimen. Results: revealed that more than half (53%) of patients had poor knowledge before implementation of the program, which improved post and follow-up program implementation (79%). Regarding to patients' compliance toward therapeutic regimen, findings indicated that, less than half (45%) of the patients had low level of compliance prior implementation of the program, which improved to high level of compliance (77%) post and follow-up program implementation. Conclusion: The results had shown many areas of deficit in patients' compliance toward therapeutic regimen prior application of the program which reflects a need for further continuous education which will provide patients with some directions that will help to be compliant with therapeutic regimen and manage complications. Recommendations: The study recommended for further continuous educational programs to be conducted for the patients to improve their compliance.