Urinary diversion is associated with significant changes in urinary and sexual function, interpersonal relationships and psychosocial stress which ultimately affect patient's perceived quality of life (QoL).The aim of this study was to evaluate the effect of self-care learning package on the quality of life for patients undergoing urinary diversion Subjects and Methods: The study was carried out at urology unit of General Benha Hospital at Benha University and Urology and Nephrology Center of Mansoura University Hospitals. Sample included 100 patients whose undergoing urinary diversion from both sexes. The researcher used 3 tools in this study including, patient's assessment questionnaire, Interviewing questionnaire sheet, Functional Assessment of Cancer Therapy- Vanderbilt Cystectomy Index, (FACT-VCI). Results: the study results revealed that, highly statistically significant improvement in studied group about their total knowledge score, and total practice with subsequent improvement in total quality of life score for studied subjects with ileal loop conduit and orthotopic ileal neobladder after implementation of self-care learning package. Conclusion: Self care learning package have positive effect on quality of life for patients with different types of urinary diversion, and the mean score of knowledge, and practice improved significantly after application of self care learning package. Recommendation: The study recommended the application of guiding educational and cultural programme for patients with urinary diversion to improve their self-care for urinary diversion.