Background: Brain tumors are often deadly, impact quality of life, and change everything for patients and their loved ones.. Therefore, measuring quality of life in those patient is important especially as Patients with primary brain tumors face serious challenges to their QOL. The aim of the present study was to assess health related quality of life among patients with brain tumor. Methods: Descriptive study design was used. It was conducted at outpatient clinic of neurology at Mansoura University Hospital, Egypt Sociodemographic sheet was developed and tested by the researcher after extensive review of related literature, it was written in simple Arabic language and covered patient's age, sex, marital status, level of education, occupation, residence and income, past and present history; It was comprised of questions about past and present medical history, previous hospitalization, previous surgery, family health history ,Tool II, The Functional Assessment of Cancer Therapy-General (FACT-G) Scale , it was used to assess patient's own quality of life. Results: The studied subjects age was ranged between 19-60 years , the majority of subjects were female &about (98%0) have weak income; about 92% of subjects have no previous cancer , Conclusion: regular assess HRQOL in neuro-oncology practice may improve quality of care by facilitating doctor- patient communication and patient participation in treatment decisions at every stage of the disease. Recommendation: The pattern of HRQOL assessment may serve as an easy and cost-effective tool to recognize early changes in the subjective clinical condition of brain tumor patients, and the relationship with disease progression and helpful in evaluating cancer care outcomes and also have been recently evaluated as early independent predictors of survival