Background: Chronic kidney disease (CKD) is a worldwide public-health problem in which most of the physical functions of the body are affected including sexual function. Apart from physical impacts due to renal failure, there are a number of psychological impacts that may also contribute to changes in sexual functioning. Therefore, the aim of this study is to assess the prevalence of psychosexual dysfunctions experienced by hemodialysis male patients. Methods: A descriptive cross-sectional research design was conducted in the hemodialysis units at Mansoura Urology and Nephrology Center. The data were collected from 100 hemodialysis male patients who corresponded to the inclusion criteria. Arizona Sexual Experience Scale (ASEX) and Psychosexual Dysfunction Questionnaires were used to achieve the purpose of the study. Results: The results indicate that (94%) of the study sample complain of psychosexual dysfunctions. The most prevalent psychosexual dysfunctions are psychosexual discomfort, fatigue, low self-esteem during sex, difficulty in reaching orgasm, difficulty in maintenance erection and low sexual desire while suicidal ideation was the lowest prevalent psychosexual dysfunctions. Conclusion: The vast majority of the study sample has psychosexual dysfunctions. Application of psychiatric liaison nursing program in hemodialysis units is recommended.