Oncology nurses play role in the care of individuals and their families in all stages of cancer, from diagnosis to death. Aim of the study: Assess nurses' attitudes toward death and caring for dying patients at Oncology Center Mansoura University. Method: A descriptive research design. Study Subjects: All available nurses (50) provide direct care for patient at end of life. Tool: One tool used for data collection Nurses' attitudes toward death and caring for dying patients questionnaires, adopted by DeKock (2011). Results: Revealed (100%) of study subject perceived as severe total general attitude towards care. On other hand, (58%) of study subject perceived as moderate of total work satisfaction, and (42%) perceived them to be of severe. Show that (86%) of the study subject perceived as severe total support in the working environment of oncology nurse and (14%) perceived them to be of moderate. Conclusion: Oncology nurses working at Oncology Center - Mansoura University have positive attitudes toward death and caring for dying patients and observed that the scores for environmental support were much higher than the ranges for work satisfaction.