Abstract: Coronary heart disease (CHD) has been the most common cause of death for both women and men. CHD is a chronic condition needing long-term rehabilitation measures to decrease mortality, morbidity and improve quality of life. Cardiac rehabilitation (CR) is a long- term multifactor rehabilitation program aimed at the secondary prevention of cardiovascular events. Therefore, the aim of the study was examine the effect of cardiac rehabilitation program on cardiac physiological risk parameters of patients with coronary heart disease. Methods Quasi-experimental research design was conducted in the inpatient & outpatient for follow up unit in cardiology department of the Specialized Medical Hospital at Mansoura University Hospital. Convinces sample of this study composed of 74 adult patients of both sexes who corresponded to inclusion criteria and divided alternatively into two equal groups study and experimental. Results the result indicates significant improvement in physiological risk parameters in study group after rehabilitation sessions. Conclusion positive effect of cardiac rehabilitation program on improvement of cardiac physiological risk parameters of CHD patients.