Abstract
Background: Helicobacter pylori (H.pylori) infection is common in Egypt. It is implicated in causation of both hyperemesis gravidarum (H.G) and rosacea (chronic skin disease). It is diagnosed by positive serum IgG antibodies.Objective: is to detect any possible relationship between infection with H.pylori and (H.G) when associated with rosacea.Design: prospective controlled study.Setting: Ob. & Gyn., dermatology and clinical pathology departments, Mansoura Faculty of Medicine, Egypt.Subjects : 266 non obese women, singleton pregnancy, divided into three groups; group (I): H.G without rosacea (n=108), group (II): H.G with rosacea (n=46) and group (III), 112 pregnant women without H.G or rosacea. Results: No statistically significant difference (P>0.05) regarding age, gravidity, gestational age and Body mass index between three groups. Regarding the positive cases, from the qualitative and the quantitative point of view, IgG antibodies (group II versus III) showed extremely significance (P = 0.001), while group I versus II and I versus III showed significant difference (P = 0.019 & 0.021) respectively. Erythematous lesions of rosacea showed the most prevalent and significant skin lesion compared to papules and pustules (P = 0.14 and 0.15) respectively.Conclusions and recommendations: H.pylori infection is sugegsted to be one of the important factors in the pathogenesis of (H.G). When rosacea is associated with (H.G), the obstetrician should expect that H.pylori is often the culprit responsible for the pathogenesis of both. We recommended more studies to clarify the different non teratogenic drugs which can be used for eradication of H.pylori during the period of organogenesis. Hence a specific and a causative treatment of H.G. will be elicited.