The study included 731 full term babies aged 1-6 days, presented with hyperbilirubinaemia (S.bilirubin > 12 mg/dl) in the period from 1985 to 1989. The babies and their mothers were subjected to I) full history taking and thorough clinical examination 2) determination of S. bi Itrubtn, Hb% and reticulocyte count in infants 3) blood group typing ABO, Rho and antibody screening for mothers and babies, tn some instances they were typed for other blood group systems. 4) IgG an­tibodies (anti-A and anti-B) was done in ABO incompatible pregnancies. It was found that out of the 731 cases with hyperbilirubinaemia, 73 ba­bies (9.99%) had HDNB. In the fater group, anti-D was detected in 24 in­fants (32.88%), anti-D and anti-C in 4 cases (5.48%), anti-c in 8 cases (10.96%), ABO incompatibility in 34 cases (46.58%) and each of anti Fya, anti-Jka, & anti-K in one case (1.37%) The results of the work showed that HDNB due to foetomaternal blood group incompatibility still a major prob­lem which needs concern. Abbreviation (Fya : Duffy a; Kidd a; K : Kelt; D. C : direct coombs, E. T : exchange transfusion).