Background arc] aim. We aim to eeteririhe the role c^f MSG compared with high caloric chow (HCC) in de­velopment of cbosilypregnant rats and thei- offspring.
Materials and Methods. Ninety pregnant ^rals were divided into 3 groups control MSG and HCC fed. We 'Jetfirrnined body weight (BW), boly fat, fat to body weight ratio, ser­um g'ucc.se, insu'in, leptin, Lpid pro­file, ob and lept'n receptor-b gene ex­pressions in pregnant rats and ob and l&ptin recepto;-b gene expressions, serum ins'jlin, glucose, leptin, triacyl-glycerides, total lipids and body weight in offspring.
Results- Daily food intake and BW
deceased wh^;!e body ^fat and fat body weight ratio increased in MSG relative to HCC ted rais. MSG or HCC increased Ob gene expression, ioptin, insulin, LDL, VLDL. choleste­rol, 'otal lipids (TL), glucose and de­creased ieptm receptor-b gene ex­pression. In orfsoring of MSG treated rats. BW, serum glucose, insulin, itp-lin, triacylgiyc'c-rlops. TL and Ob gene expression increased and leptin re­ceptor-b gene expression decreased whereas in offspring of HCC fed rats, serum insulin, iepun, Ob and Ieptm re-cepior-b gene expression increased but no significant increase in serum glucose, triacylglycerides, TL or BW.