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P53 AND MICROVESSEL DENSITY (MVD) IN INVASIVE BREAST CARCINOMA: IMMU-NOHISTOCHEMICAL STUDY.

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Last updated: 04 Jan 2025

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Abstract

Background and aim : Carcinoma of the breast is the most prevalent cancer among Egyptian women. P53 overexpression is the most common genetic alteration found in breast can­cer. The growth and proliferation of tumor cells, as well as their metastat-ic dissemination, have been shown to be preceded and facilitated by the for­mation of new blood vessels (angio-genesis). This work aimed to deter­mine p53 expression and angiogenesis measured by microves-sel density (MVD) in invasive breast carcinoma. Also, to study the relation­ship between p53 expression and the degree of angiogenesis.
Patients and methods : The present study was performed on the paraffin blocks from the tumors of 40 modified radical mastectomy speci­mens (done for invasive breast carci­noma). Immunohistochemical staining for p53 and CD34 (marking endo-thelial cells for MVD assessment) was done.
Results : In this study, p53 was positive in 60 % of invasive breast carcinomas. P53 positivity was high­est in tumors of patients in the fifth decade, premenopausal, tumors of grade II, with a size of 2-5 cm, with positive axillary L.Ns and stage MB.

DOI

10.21608/mjmu.2008.129211

Authors

First Name

Iman

Last Name

El-Salkh

MiddleName

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Affiliation

Deprtments of pathology Faculty of Medicine , Mansoura University , Mansoura , Egypt

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Orcid

-

First Name

Nadia

Last Name

Atwan

MiddleName

-

Affiliation

Deprtments of pathology Faculty of Medicine , Mansoura University , Mansoura , Egypt

Email

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-

Orcid

-

First Name

Soheir

Last Name

Sirag

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-

Affiliation

Deprtments of pathology Faculty of Medicine , Mansoura University , Mansoura , Egypt

Email

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City

-

Orcid

-

First Name

Maha

Last Name

Abu hashim

MiddleName

-

Affiliation

Deprtments of pathology Faculty of Medicine , Mansoura University , Mansoura , Egypt

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-

Orcid

-

First Name

Khaled

Last Name

Zalata

MiddleName

-

Affiliation

Deprtments of pathology Faculty of Medicine , Mansoura University , Mansoura , Egypt

Email

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City

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Orcid

-

First Name

Hany

Last Name

Onsy

MiddleName

-

Affiliation

Deprtments of pathology Faculty of Medicine , Mansoura University , Mansoura , Egypt

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City

-

Orcid

-

First Name

Ibrahim

Last Name

Awad

MiddleName

-

Affiliation

Deprtments of Clinical Oncology and Nuclear Medicine Faculty of Medicine , Mansoura University , Mansoura , Egypt

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-

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Volume

37

Article Issue

2

Related Issue

19197

Issue Date

2008-12-01

Receive Date

2020-12-12

Publish Date

2008-12-01

Page Start

357

Page End

371

Print ISSN

1110-211X

Online ISSN

2735-3990

Article File

MJMU_Volume 37_Issue 2_Pages 357-371.pdf

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Link

https://mjmu.journals.ekb.eg/article_129211.html

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https://mjmu.journals.ekb.eg/service?article_code=129211

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Type

Research (original) articles

Type Code

1,453

Publication Type

Journal

Publication Title

Mansoura Medical Journal

Publication Link

https://mjmu.journals.ekb.eg/

MainTitle

P53 AND MICROVESSEL DENSITY (MVD) IN INVASIVE BREAST CARCINOMA: IMMU-NOHISTOCHEMICAL STUDY.

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Article

Created At

23 Jan 2023