Severe infection and inflammation almost invariably lead to hemostatic abnormalities, ranging from insignifi­cant laboratory changes to severe disseminated intravascular coagula­tion (DIG). The aim was to assess the effect of infection on coagulation par­ameters in infected burn wound that could predict for the development of DIG in those patients. This study in­cluded 60 patients (16 6 & 44 O ), with mean age of 32.9±10.5 years, they were treated in burn surgery unit Mansoura University Hospitals. They were classified into two groups, group I included 38 patients with burn wound infection, and group II included 22 patients with clean burn wound (control group). All cases were sub-
jected to through history taking and clinical examination. For cases with infected wounds, sterile swabs were used for aspiration of deeply seated wound pus for microbiologic examina­tion. Blood samples were collected for prothrombin time (PT), activated par­tial thromboplastin time (APTT), plate­let count and fibrinogen concentration detection. This study revealed fe­males (73.3%) were mostly affected by burn insults than males (26.7%). Out of 60 studied cases 61.7% had 3rd degree of burn and 63.3% devel­oped burn wound infection. The most frequently isolated organisms from in­fected wound (38) were pseudomo-nas aeruginosa (31.6%), E.coli (18.4%), proteus (13.2%), coagulase negative Staphylococci (coag. -ve