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127744

THE PROTECTIVE ROLE OF ANTI-OXIDANT BETA-CAROTENE ON SCHISTOSOMA MANSONI INFECTED MUR1NE MICE

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Last updated: 23 Jan 2023

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Abstract

Schistose mi as is is the second most prevalent tropical disease in the world after malaria and is caused by the Schistosoma, genus of fluke. The pathophysiology of schistosomiasis is due to the immune response against the schistosome eggs. The clinical manifestations depend on the species of parasite, intensity of worm burden, and immunity of the person to the parasite. Many trials were done for production of vaccine against infec­tion of shistosomiasis and many ef­forts were spent to prevent infection, but the rate of new cases is still high. On the other hand, we need a meth­od to prevent or at least decrease the
inflammatory reaction caused by schistosomiasis. This study aimed to the evaluation of possible protective effect of anti-oxidant b-carotene on S.mansoni infected mice or decrease the inflammatory reaction caused by schistosomiasis. Sixty nice were included in this study and they were divided into 4 groups, every group is 15 mice:Group (1): (treated infected group); Group (2): {treated non-infected group); Group (3): {infected group) and Group (4): (normal con­trol). The results: b-carotene reduced worm burden to about 20%, fa-carotene significantly reduced hepatic and intestinal tissue egg load with a reduction percentage of 26%

DOI

10.21608/mjmu.2005.127744

Authors

First Name

Saed

Last Name

Ruzik

MiddleName

-

Affiliation

Tropical Medicine Department, Cairo Faculty of Medicine, AL-Azhar University

Email

-

City

-

Orcid

-

First Name

Saleh

Last Name

Alebiary

MiddleName

-

Affiliation

Tropical Medicine Department, Cairo Faculty of Medicine, AL-Azhar University

Email

-

City

-

Orcid

-

First Name

Mohamed

Last Name

Bastawy

MiddleName

-

Affiliation

Tropical Medicine Department, Cairo Faculty of Medicine, AL-Azhar University

Email

-

City

-

Orcid

-

First Name

Mostafa

Last Name

Abou Alnga

MiddleName

-

Affiliation

Anatomy and Emberyology Department, Damietta Faculty of Medicine, AL-Azhar University

Email

-

City

-

Orcid

-

First Name

Samy

Last Name

Zaky

MiddleName

-

Affiliation

Tropical Medicine Department, Damietta Faculty of Medicine, AL-Azhar University5

Email

-

City

-

Orcid

-

First Name

Nabil

Last Name

AInoamani

MiddleName

-

Affiliation

Tropical Medicine Department, Damietta Faculty of Medicine, AL-Azhar University5

Email

-

City

-

Orcid

-

First Name

Mohamed

Last Name

Hishmat

MiddleName

-

Affiliation

Parasitology Department, Medical Research Institute,Alexandria University

Email

-

City

-

Orcid

-

First Name

Mohamed

Last Name

Tawfik

MiddleName

-

Affiliation

Tropical Medicine Department, Beni-Suef Faculty of Medicine, Cairo University

Email

-

City

-

Orcid

-

First Name

Ashraf Z.

Last Name

EI-Sayed

MiddleName

-

Affiliation

Zoology Department, Faculty of Science, Al-Azhar University

Email

-

City

-

Orcid

-

Volume

34

Article Issue

1

Related Issue

19045

Issue Date

2005-04-01

Receive Date

2020-12-06

Publish Date

2005-04-01

Page Start

1

Page End

17

Print ISSN

1110-211X

Online ISSN

2735-3990

Article File

MJMU_Volume 34_Issue 1_Pages 1-17.pdf

PDF . 4.3MB

Link

https://mjmu.journals.ekb.eg/article_127744.html

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https://mjmu.journals.ekb.eg/service?article_code=127744

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Type

Research (original) articles

Type Code

1,453

Publication Type

Journal

Publication Title

Mansoura Medical Journal

Publication Link

https://mjmu.journals.ekb.eg/

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Article

Created At

23 Jan 2023