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127471

CHARACTERIZATION OF HEPATITIS B AMONG INCIDENTALLY DETECTED ASYMPTOMATIC HEPA- TITIS B SURFACE ANTIGEN (HBSAG) POSITIVE SUBJECTS IN EGYPT

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Last updated: 23 Jan 2023

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Abstract

Background : Although chronic hepatitis B virus infections are common in Egypt, the incidentally discovered asymptomatic forms are very frequent. Their serological profile and clinical significance have not been determined.
Aim : To characterize the clinical, serological and histological liver dam­age among incidentally detected asymptomatic hepatitis B surface anti­gen (HBsAg)-positive subjects (IDAHS) in Egypt.
Methods : We prospectively stud­ied 70 consecutive IDAHS patients
who were long term HBsAg carriers. Tests for liver function, serologica! markers for HBV, HCV, HDV and schistosomiasis were done for all pa­tients. HBV DNA was determined by the branched DNA technique and PCR at the core promotor/precore re­gion and the S region. Liver biopsy specimens from 44 patients were studied and scored for activity and fib-rosis stage by modified Knodell score and the METAVIR score. HBsAg and HBcAg were immunohistochemically evaluated in the liver tissue.
Results : Of the studied 70 pa­tients, 57 (81.6%) were HBeAg-negative and 13 (18.4%) were

DOI

10.21608/mjmu.2003.127471

Authors

First Name

G

Last Name

SHIHA

MiddleName

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Affiliation

Internal Medical Department, Et-Mansoura Faculty of Medicine'

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First Name

A

Last Name

ELFAKHRY

MiddleName

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Affiliation

Internal Medical Department, Et-Mansoura Faculty of Medicine'

Email

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-

First Name

A

Last Name

MENESY

MiddleName

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Affiliation

Internal Medical Department, Et-Mansoura Faculty of Medicine'

Email

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City

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Orcid

-

First Name

S

Last Name

SIEF

MiddleName

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Affiliation

Internal Medical Department, Et-Mansoura Faculty of Medicine',

Email

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City

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Orcid

-

First Name

M

Last Name

GABER

MiddleName

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Affiliation

Internal Medical Department, Tanta Faculty of Medicine

Email

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City

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Orcid

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First Name

A

Last Name

MONIS

MiddleName

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Affiliation

Internal Medical Department, Ain Shams Faculty of Medicine

Email

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Orcid

-

First Name

A

Last Name

ELBAZ

MiddleName

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Affiliation

Internal Medical Department Medical Biochemistry Department EI-Mansoura Faculty of Medicine

Email

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City

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Orcid

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First Name

K

Last Name

ZALATA

MiddleName

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Affiliation

Medical Biochemistry Department EI-Mansoura Faculty of Medicine

Email

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City

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Orcid

-

First Name

S

Last Name

ELSAYED

MiddleName

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Affiliation

Pathology Department5, EI-Mansoura Faculty of Medicine

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Volume

33

Article Issue

2

Related Issue

19044

Issue Date

2003-12-01

Receive Date

2020-12-05

Publish Date

2003-12-01

Page Start

367

Page End

385

Print ISSN

1110-211X

Online ISSN

2735-3990

Article File

MJMU_Volume 33_Issue 2_Pages 367-385.pdf

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https://mjmu.journals.ekb.eg/article_127471.html

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https://mjmu.journals.ekb.eg/service?article_code=127471

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7

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Research (original) articles

Type Code

1,453

Publication Type

Journal

Publication Title

Mansoura Medical Journal

Publication Link

https://mjmu.journals.ekb.eg/

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Article

Created At

23 Jan 2023