Background : Atopic dermatitis (AD) is an inflammatory skin disease that constitutes a significant burden to patients and their families. Parasitic infections as well are a cause of ex­tensive morbidity in most tropical countries. Eosinophils are the pre­dominant cells involved in these con­ditions. Upon activation of eosinophils by T helper 2 (Th-2) cytokines and their own mediators, they release granule proteins which can kill para­sites and mediate inflammation in AD. Aim: the present study aimed to as­sess serum IgE and ECP and inter-leukines (IL-5 and IL-13) expression in atopic dermatitis and parasitic in­fection and their relation to disease activity. Subjects and methods: the present work was conducted on 45 patients, classified into group I: AD
(15 patients), group II: parasitic infec­tion (Ascraisis and Schistomiasis) comprised 15 patients and group III: parasitic infection associated with al­lergic skin disease. In addition, 15 healthy subjects of matched age and sex were enrolled as a reference group. Results: Serum ECP and IgE levels were significantly elevated in all studied patient groups compared to the control and in group II and III com­pared to group I while insignificant dif­ference was noted between group II and III. Eosinophil percent was signifi­cantly elevated in all patient groups compared to controls, but insignificant difference was found between patient groups. Moreover, serum IgE, ECP and eosinophil percent were signifi­cantly elevated in severe AD sub­group compared to moderate AD cas­es.