BACKGROUND : Expression of nm23 has been shown to be inversely correlated with the metastatic potential of several human cancers. The objective of this study is to evaluate the value of nm23, and Ki-67 as prognostic markers in patients with color-ectal carcinoma
METHODS: We conducted a retrospective analysis on 56 patients with colorectal carcinoma. Immuno-histochemistry (IHC) was performed on archival formalin fixed paraffin embedded sections. Antibodies to nm23 and Ki-67 were used. This was correlated with the following clinicopatho-logic parameters: patient sex, age
and survival, stage, and grade of the tumors. i":v "
RESULT: Among the 56 cases of colorectal cancer there were 24 female and 32 male. (Male/female=1.3). The mean age was 54.9 years (range 30-80 years). Two of the cases were Dukes' stage A, 28 (stage B), 18 (stage C) and 8 (stage D). Ki-67 was positive in 94%(n=53). The positivity in different stages was as follows (2/2 stage A, 26/28 stage B, 17/18 stage C and 7/8 stage D), Normal mucosa adjacent to cancer showed positive staining for ki-67 in 18/56. nm23 was positive in 84% (n=47) of tumors compared to 45/56 of normal mucosa. The positivity in different stages