Insulin resistance is known to be a risk factor for the development of type II diabetes mellitus, cardiovascular diseases associated with dyslipidemia & obesity. The present work aimed at the investigation of the influence & possible mechanism of either pravas­tatin or captopril on contractile re­sponse of the isolated aortic strip to noradrenaline (NA) in rats with esta­blished insulin resistance induced by high fructose diet Furthermore to our knowledge there is no study compar­ing the effect of pravastatin & capto­pril as regarding the biochemical changes associated with insulin resis­tance in rats. The present study was carried out on fourty-eight male albino rats. Rats were divided into 2 main groups:Group (A); consisted of 12 animals that received standard diet through the experiment {8 weeks) & treated with intragastric saline (the ve­hicle), starting from the last 2 weeks of experiment & served as normal control. Group (B); consisted of 36 animals, received high fructose diet (for 8 weeks) for induction of insulin resistance. This group was subdivid­ed into 3 equal subgroups (12 rats / subgroup ) as the following: subgroup (b1); served as insulin resistant con­trol, treated with saline, subgroup (b2); insulin resistant rats treated with pravastatin in a dose of 20 mg/kg/day, intragastrically in the last 2 weeks of the experiment, subgroup (b3): re­ceived high fructose diet (insulin re­sistant) & treated with captopril in a dose of 2 mg/kg/day intragastrically in the last 2 weeks of the experiment.