Background: Numerous factors affect the development of left ventric -far hypertrophy & dysfunction in end stage renal disease. Among those, ar-teriovenous fistulae emerged as an important factor. These fistulae undergo surgical closure following successful renal transplantation. However, sudden closure of arterivenous fistulae after its presence for long time may have an implications on feft ventricular diastolic performance & may precipitate heart failure.
Objectives : To assess the possible impact of AV closure on diastolic function we prospectively examined 24 patients with ESRD with AV fistulae on regular haemodialysis before & after temporary complete fistulae oc-
clusion. EchoDoppler parameters of diastolic function including transrnitral early filling (E) & atrial filling (A) wave acceleration & deceleration times, transmitral E & A wave peak & mean velocities & gradients, transmitral E & A wave velocity time integrals . heart rate .& isovolumtc relaxation time.
Results : Transmitral (E) & (A) wave acceleration times were significantly snorter while transmitral (E) & (A) wave deceleration times were significantly longer after than before sudden fistulae occlusion. Heart rate was significantly slower after than before temporary fistulae occlusion. There were non significant trend for E/A peak & mean velocity & gradient decrease or reversal & increase in isovolumic relaxation time after than