Thrombolytic therapy, the impor­tant therapeutic agents in pa­tients with acute myocardial infarction has been reported to be asso­ciated with significant early onset protenuria.
The aim of this study was to deter­mine whether streptokinase therapy is associated with changes in renal function (both glomerular and tubular) in excess of that expected in an acute vascular event; and the possible path-ogenesis of any observed changes among patients with uncomplicated acute myocardial infarction.
Our work comprised 30 patients with uncomplicated acute myocardial infarction selected from coronary care unit Mansoura Emergency Hospital.
They comprised 15 patients who received streptokinase therapy {thrombolytic group) and 15 patients who did not receive strep­tokinase therapy (non thrombolytic group).
Laboratory tests reflecting both glomerular functions {serum create-nine createnine clearance and urinary albumin excretion) and tubular func­tions {serum and urinary B2 micro-globulin) were estimated for every pa­tient on admission; 24 hours after initiation of therapy as well as on the 7th day of therapy.
The results showed:
A) Non significant changes in renal functions among patients with acute myocardial infarction not receiving thrombolytic therapy