Insulin resistance or compensatory hyperinsulinemia has been associated with dyslipidemia. Tumour necrosis factor-( (TNF-ci) may be an important circulating cytokine which may provide a potentially reversible mechanism for mediating insulin resistance.
The present study was carried out to compare the be. ^ricial effect of either the oral antidiabetic (metformin) or the angiotensin converting enzyme inhibitor (captopril) on insulin sensitivity in rats fed high-fructose diet for 9 weeks. Other contribution of this work is to find if the improving effect of metformin or captopril on insulin resistance occurs through modulation of TNF-cx or not. 108 male albino rats were used throughout this study. The animals were divided into 6 equal groups (n=18). Group (1) served as a control received standard diet for 9 weeks. Group (2) received high fructose diet for 9 weeks. Group (3) received standard diet for 9 weeks and metformin treatment in a dose of 200 mg/kg/day in the last 3 weeks. Group (4) received high fructose diet for 9 weeks and metformin treatment in the last 3 weeks. Group (5) received, standard diet for 9 weeks and captopril treatment in a dose of 2 mg/kg/day in the last 3 weeks. Group (6) received high fructose diet for 9 weeks and captopril treatment in the last 3 weeks. Insulin sensitivity test, intravenous glucose tolerance test (IVGTT), fasting serum insulin were all used to determine insulin sensitivity. In addition lipogram