Insulin resistance or compensatory hyperinsulinemia has been associat­ed with dyslipidemia. Tumour necro­sis factor-( (TNF-ci) may be an impor­tant circulating cytokine which may provide a potentially reversible mech­anism for mediating insulin resis­tance.
The present study was carried out to compare the be. ^ricial effect of either the oral antidiabetic (metformin) or the angiotensin converting enzyme inhibitor (captopril) on insulin sensitivity in rats fed high-fructose diet for 9 weeks. Other contribution of this work is to find if the improving effect of metformin or captopril on insulin resistance occurs through modulation of TNF-cx or not. 108 male albino rats were used throughout this study. The animals were divided into 6 equal groups (n=18). Group (1) served as a control received standard diet for 9 weeks. Group (2) received high fructose diet for 9 weeks. Group (3) received stan­dard diet for 9 weeks and metformin treatment in a dose of 200 mg/kg/day in the last 3 weeks. Group (4) re­ceived high fructose diet for 9 weeks and metformin treatment in the last 3 weeks. Group (5) received, standard diet for 9 weeks and captopril treat­ment in a dose of 2 mg/kg/day in the last 3 weeks. Group (6) received high fructose diet for 9 weeks and captopril treatment in the last 3 weeks. Insulin sensitivity test, intravenous glucose tolerance test (IVGTT), fasting serum insulin were all used to determine in­sulin sensitivity. In addition lipogram