Non-Hodgkin's lymphomas are a diverse group of tumours which show morphologically a heterogenous wide spectrum of disease complexes and often unpredictable response to treat­ment. Clinically they vary from fulmi­nate conditions to chronic indolent processes (Jelliffe, 1986).
According to the Working Formu­lation, the NHLs are grouped into three broad prognostic categories, low, intermediate and high grade dis­eases. Low grade NHLs are com­posed of three histologic subtypes by the Working Formulation: small lym-phocytic (SLL), follicular small cleaved cell (FSCL) and follicular mixed small cleaved and large cell (FML).
Whereas radiotherapy is potiential-ly curative in localized disease (stage I and II), the most appropriate man­agement of wide-spread lymphoma remains controversial. Current thera­peutic modalities range from a cau­tious "Watch and Wait" approach, through chemotherapy of moderate intensity, to aggressive muftidrug regi­mens combined with total nodal irradi­ation (Young et al., 1988 and Port-lock, 1990).
The aim of this work is review of different treatment modalities of newly diagnosed low grade NHL patients with analysis of the prog­nostic factors for response and survival.