The use of Video Display Termi­nals (VDTs) has increased dramati­cally in the past 10 years and is pro­jected to increase. Particular concerns related to the use of VDTs include vision, dermatological, repro­duction, stress and ergonomics has been directed. To evaluate the asso­ciation between VDT use and the ad­verse conditions related to vision, musculoskeletal conditions, skin, fe­male reproductive conditions and psy­chological conditions, we conducted this cross-sectional study. The study group consisted of clerical workers exposed to VDTs in Port Said, fsmai-lia and Suez cities for at least 12 hours weekly for at least one year. A control group selected from the same worksite with the same work-force characteristics but not exposed to VDTs. The two groups were matched with each other as regards sex and age. The sample size turned to be 150 workers per a group. A question­naire was used for the collection of personal and occupational data as well as health events of various body systems. Taylor and Zung self-rating scales were used for measuring anx­iety and depression, respectively among our population. Screen char­acteristics were also asked for blood pressure and visual acuity were measured for each person included in the study. The results of this study in­dicated an increased prevalence of adverse conditions pertaining to mus­culoskeletal discomfort, menstrual disorders, visual disorders, dermato-logical disorders and anxiety (using Taylor self-rating scale) among cleri­cal workers who used VDTs.