Dyslipidemia is one of the major risk factors for ischemic heart diseases.
Vegetable oils as flaxseed and corn oils draw the attention because they
owe many health benefits as antioxidant and anti-inflammatory. Objectives:
This work aimed to study the possible role of flaxseed and corn oils in prevention
or attenuation of acute myocardial infarction in male rats fed a high
fat
diet. Methods:
64 adult male rats were divided into 4 groups:
group standard diet fed rats,
(2)
high fat fed group < br /> (3)
high fat diet and supplemented
with flaxseed oil and
(1)
control
(4)
high fat diet and supplemented with
corn oil group. After 8 weeks myocardial infarction was induced by isoprenaline
injection for 2 consecutive days. ECG, serum lipid profile and serum
CK-MB
were assessed. Results:
Flaxseed
oil supplementation produce significant
increase in QRS amplitude, shortening of QTc interval and less ST
elevation.
Flaxseed oil improved the lipid profile and decreased the serum
level
of CK-MB. Whereas corn oil supplementation showed, a significant decrease
in ST segment elevation but insignificant change in QRS amplitude,
and
QTc interval. Corn oil significantly decrease CK-MB but less than flaxseed
oil. Conclusion:
Flaxseed and corn oils exhibit cardioprotective effects
in
attenuation of acute myocardial infarction in rats fed a high fat diet. Flaxseed
oil has more cardioprotective effects may be attributed to its higher
content
of omega 3 fatty acids.